Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies
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چکیده
منابع مشابه
Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies
The HIV envelope glycoprotein (Env) is densely covered with self-glycans that should help shield it from recognition by the human immune system. Here, we examine how a particularly potent family of broadly neutralizing antibodies (Abs) has evolved common and distinct structural features to counter the glycan shield and interact with both glycan and protein components of HIV Env. The inferred ge...
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Antibodies that are present in the serum of healthy individuals in the absence of deliberate immunization with any antigen, are refered to as natural antibodies. A vast majority of natural antibodies react with one or more self antigens and are termed as natural autoantibodies. The importance of natural autoantibodies in immune regulation has long been neglected, since tolerance to self was tho...
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The traditional definition of natural antibodies (NAbs) states that these antibodies are present prior to the body encountering cognate antigen, providing a first line of defense against infection thereby, allowing time for a specific antibody response to be mounted. The literature has a seemingly common definition of NAbs; however, as our knowledge of antibodies and B cells is refined, re-eval...
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ژورنال
عنوان ژورنال: Cell
سال: 2021
ISSN: 0092-8674
DOI: 10.1016/j.cell.2021.04.042